Nicotine and other cognitive enhancers

I just read a great blog entry on nicotine and it's effects on the brain written by Madam Fathom. She give a great review of how the nerves in the prefrontal cortex behave and how they are effected by nicotine in both a person that smokes and a nonsmoker. I would love for her to do a similar story on modafinil. The maker, Cephalon, claims there is no negative side effects and information from a resent ongoing study seems to indicate what college kids and silicon valley body hackers already know. It improves memory and seems to have a similar effect to nicotine, in that it "may enhance the signal-to-noise ratio" allowing people to concentrate better.